A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV
Identifieur interne : 000A94 ( Main/Exploration ); précédent : 000A93; suivant : 000A95A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV
Auteurs : Guangyu Zhao [République populaire de Chine] ; Lei He [République populaire de Chine] ; Shihui Sun [République populaire de Chine] ; Hongjie Qiu [République populaire de Chine] ; Wanbo Tai [République populaire de Chine, États-Unis] ; Jiawei Chen [États-Unis] ; Jiangfan Li [République populaire de Chine] ; Yuehong Chen [République populaire de Chine] ; Yan Guo [République populaire de Chine] ; Yufei Wang [États-Unis] ; Jian Shang [États-Unis] ; Kaiyuan Ji [République populaire de Chine] ; Ruiwen Fan [République populaire de Chine] ; Enqi Du [République populaire de Chine] ; Shibo Jiang [États-Unis] ; Fang Li [États-Unis] ; Lanying Du [États-Unis] ; Yusen Zhou [République populaire de Chine]Source :
- Journal of Virology [ 0022-538X ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps neutralisants (), Anticorps neutralisants (immunologie), Anticorps à domaine unique (immunologie), Anticorps à domaine unique (isolement et purification), Anticorps à domaine unique (métabolisme), Anticorps à domaine unique (économie), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Infections à coronavirus (), Infections à coronavirus (immunologie), Liaison aux protéines, Sites de fixation (immunologie), Souris, Souris de lignée BALB C, Tests de neutralisation, Épitopes (métabolisme).
- MESH :
- génétique : Glycoprotéine de spicule des coronavirus.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Anticorps à domaine unique, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Sites de fixation.
- isolement et purification : Anticorps à domaine unique.
- métabolisme : Anticorps à domaine unique, Épitopes.
- économie : Anticorps à domaine unique.
- Animaux, Anticorps neutralisants, Humains, Infections à coronavirus, Liaison aux protéines, Souris, Souris de lignée BALB C, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (chemistry), Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Binding Sites (immunology), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (therapy), Epitopes (metabolism), Humans, Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Neutralization Tests, Protein Binding, Single-Domain Antibodies (economics), Single-Domain Antibodies (immunology), Single-Domain Antibodies (isolation & purification), Single-Domain Antibodies (metabolism), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , chemistry : Antibodies, Neutralizing.
- chemical , economics : Single-Domain Antibodies.
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Single-Domain Antibodies, Spike Glycoprotein, Coronavirus.
- immunology : Binding Sites, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- chemical , isolation & purification : Single-Domain Antibodies.
- chemical , metabolism : Epitopes, Single-Domain Antibodies.
- prevention & control : Coronavirus Infections.
- therapy : Coronavirus Infections.
- Animals, Humans, Mice, Mice, Inbred BALB C, Neutralization Tests, Protein Binding.
Abstract
Therapeutic development is critical for preventing and treating continual MERS-CoV infections in humans and camels. Because of their small size, nanobodies (Nbs) have advantages as antiviral therapeutics (e.g., high expression yield and robustness for storage and transportation) and also potential limitations (e.g., low antigen-binding affinity and fast renal clearance). Here, we have developed novel Nbs that specifically target the receptor-binding domain (RBD) of MERS-CoV spike protein. They bind to a conserved site on MERS-CoV RBD with high affinity, blocking RBD's binding to MERS-CoV receptor. Through engineering a C-terminal human Fc tag, the
Url:
DOI: 10.1128/JVI.00837-18
PubMed: 29950421
PubMed Central: 6146697
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000E99
- to stream Pmc, to step Curation: 000E99
- to stream Pmc, to step Checkpoint: 000656
- to stream PubMed, to step Corpus: 000853
- to stream PubMed, to step Curation: 000853
- to stream PubMed, to step Checkpoint: 000A45
- to stream Ncbi, to step Merge: 001E80
- to stream Ncbi, to step Curation: 001E80
- to stream Ncbi, to step Checkpoint: 001E80
- to stream Main, to step Merge: 000A97
- to stream Main, to step Curation: 000A94
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV</title><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Lei" sort="He, Lei" uniqKey="He L" first="Lei" last="He">Lei He</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qiu, Hongjie" sort="Qiu, Hongjie" uniqKey="Qiu H" first="Hongjie" last="Qiu">Hongjie Qiu</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chen, Jiawei" sort="Chen, Jiawei" uniqKey="Chen J" first="Jiawei" last="Chen">Jiawei Chen</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Li, Jiangfan" sort="Li, Jiangfan" uniqKey="Li J" first="Jiangfan" last="Li">Jiangfan Li</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Yuehong" sort="Chen, Yuehong" uniqKey="Chen Y" first="Yuehong" last="Chen">Yuehong Chen</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Guo, Yan" sort="Guo, Yan" uniqKey="Guo Y" first="Yan" last="Guo">Yan Guo</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Yufei" sort="Wang, Yufei" uniqKey="Wang Y" first="Yufei" last="Wang">Yufei Wang</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shang, Jian" sort="Shang, Jian" uniqKey="Shang J" first="Jian" last="Shang">Jian Shang</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ji, Kaiyuan" sort="Ji, Kaiyuan" uniqKey="Ji K" first="Kaiyuan" last="Ji">Kaiyuan Ji</name><affiliation wicri:level="1"><nlm:aff id="aff4">ShanXi Agricultural University, Shanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>ShanXi Agricultural University, Shanxi</wicri:regionArea><wicri:noRegion>Shanxi</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Ruiwen" sort="Fan, Ruiwen" uniqKey="Fan R" first="Ruiwen" last="Fan">Ruiwen Fan</name><affiliation wicri:level="1"><nlm:aff id="aff4">ShanXi Agricultural University, Shanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>ShanXi Agricultural University, Shanxi</wicri:regionArea><wicri:noRegion>Shanxi</wicri:noRegion></affiliation></author><author><name sortKey="Du, Enqi" sort="Du, Enqi" uniqKey="Du E" first="Enqi" last="Du">Enqi Du</name><affiliation wicri:level="1"><nlm:aff id="aff5">Northwest A&F University, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Northwest A&F University, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou</wicri:regionArea><wicri:noRegion>Zhengzhou</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29950421</idno><idno type="pmc">6146697</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146697</idno><idno type="RBID">PMC:6146697</idno><idno type="doi">10.1128/JVI.00837-18</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000E99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E99</idno><idno type="wicri:Area/Pmc/Curation">000E99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E99</idno><idno type="wicri:Area/Pmc/Checkpoint">000656</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000656</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:29950421</idno><idno type="wicri:Area/PubMed/Corpus">000853</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000853</idno><idno type="wicri:Area/PubMed/Curation">000853</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000853</idno><idno type="wicri:Area/PubMed/Checkpoint">000A45</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A45</idno><idno type="wicri:Area/Ncbi/Merge">001E80</idno><idno type="wicri:Area/Ncbi/Curation">001E80</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E80</idno><idno type="wicri:doubleKey">0022-538X:2018:Zhao G:a:novel:nanobody</idno><idno type="wicri:Area/Main/Merge">000A97</idno><idno type="wicri:Area/Main/Curation">000A94</idno><idno type="wicri:Area/Main/Exploration">000A94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV</title><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Lei" sort="He, Lei" uniqKey="He L" first="Lei" last="He">Lei He</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qiu, Hongjie" sort="Qiu, Hongjie" uniqKey="Qiu H" first="Hongjie" last="Qiu">Hongjie Qiu</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chen, Jiawei" sort="Chen, Jiawei" uniqKey="Chen J" first="Jiawei" last="Chen">Jiawei Chen</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Li, Jiangfan" sort="Li, Jiangfan" uniqKey="Li J" first="Jiangfan" last="Li">Jiangfan Li</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Yuehong" sort="Chen, Yuehong" uniqKey="Chen Y" first="Yuehong" last="Chen">Yuehong Chen</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Guo, Yan" sort="Guo, Yan" uniqKey="Guo Y" first="Yan" last="Guo">Yan Guo</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Yufei" sort="Wang, Yufei" uniqKey="Wang Y" first="Yufei" last="Wang">Yufei Wang</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shang, Jian" sort="Shang, Jian" uniqKey="Shang J" first="Jian" last="Shang">Jian Shang</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ji, Kaiyuan" sort="Ji, Kaiyuan" uniqKey="Ji K" first="Kaiyuan" last="Ji">Kaiyuan Ji</name><affiliation wicri:level="1"><nlm:aff id="aff4">ShanXi Agricultural University, Shanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>ShanXi Agricultural University, Shanxi</wicri:regionArea><wicri:noRegion>Shanxi</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Ruiwen" sort="Fan, Ruiwen" uniqKey="Fan R" first="Ruiwen" last="Fan">Ruiwen Fan</name><affiliation wicri:level="1"><nlm:aff id="aff4">ShanXi Agricultural University, Shanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>ShanXi Agricultural University, Shanxi</wicri:regionArea><wicri:noRegion>Shanxi</wicri:noRegion></affiliation></author><author><name sortKey="Du, Enqi" sort="Du, Enqi" uniqKey="Du E" first="Enqi" last="Du">Enqi Du</name><affiliation wicri:level="1"><nlm:aff id="aff5">Northwest A&F University, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Northwest A&F University, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff1">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou</wicri:regionArea><wicri:noRegion>Zhengzhou</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (chemistry)</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (immunology)</term><term>Binding Sites (immunology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (therapy)</term><term>Epitopes (metabolism)</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Neutralization Tests</term><term>Protein Binding</term><term>Single-Domain Antibodies (economics)</term><term>Single-Domain Antibodies (immunology)</term><term>Single-Domain Antibodies (isolation & purification)</term><term>Single-Domain Antibodies (metabolism)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps neutralisants ()</term><term>Anticorps neutralisants (immunologie)</term><term>Anticorps à domaine unique (immunologie)</term><term>Anticorps à domaine unique (isolement et purification)</term><term>Anticorps à domaine unique (métabolisme)</term><term>Anticorps à domaine unique (économie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Liaison aux protéines</term><term>Sites de fixation (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term><term>Épitopes (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Neutralizing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="economics" xml:lang="en"><term>Single-Domain Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Single-Domain Antibodies</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Anticorps à domaine unique</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Infections à coronavirus</term><term>Sites de fixation</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Binding Sites</term><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Single-Domain Antibodies</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps à domaine unique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Epitopes</term><term>Single-Domain Antibodies</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anticorps à domaine unique</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Anticorps à domaine unique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps neutralisants</term><term>Humains</term><term>Infections à coronavirus</term><term>Liaison aux protéines</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Therapeutic development is critical for preventing and treating continual MERS-CoV infections in humans and camels. Because of their small size, nanobodies (Nbs) have advantages as antiviral therapeutics (e.g., high expression yield and robustness for storage and transportation) and also potential limitations (e.g., low antigen-binding affinity and fast renal clearance). Here, we have developed novel Nbs that specifically target the receptor-binding domain (RBD) of MERS-CoV spike protein. They bind to a conserved site on MERS-CoV RBD with high affinity, blocking RBD's binding to MERS-CoV receptor. Through engineering a C-terminal human Fc tag, the <italic>in vivo</italic> half-life of the Nbs is significantly extended. Moreover, the Nbs can potently cross-neutralize the infections of diverse MERS-CoV strains isolated from humans and camels. The Fc-tagged Nb also completely protects humanized mice from lethal MERS-CoV challenge. Taken together, our study has discovered novel Nbs that hold promise as potent, cost-effective, and broad-spectrum anti-MERS-CoV therapeutic agents.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Konning, D" uniqKey="Konning D">D Konning</name></author><author><name sortKey="Zielonka, S" uniqKey="Zielonka S">S Zielonka</name></author><author><name sortKey="Grzeschik, J" uniqKey="Grzeschik J">J Grzeschik</name></author><author><name sortKey="Empting, M" uniqKey="Empting M">M Empting</name></author><author><name sortKey="Valldorf, B" uniqKey="Valldorf B">B Valldorf</name></author><author><name sortKey="Krah, S" uniqKey="Krah S">S Krah</name></author><author><name sortKey="Schroter, C" uniqKey="Schroter C">C Schroter</name></author><author><name sortKey="Sellmann, C" uniqKey="Sellmann C">C Sellmann</name></author><author><name sortKey="Hock, B" uniqKey="Hock B">B Hock</name></author><author><name sortKey="Kolmar, H" uniqKey="Kolmar H">H Kolmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De, Mt" uniqKey="De M">MT De</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S Muyldermans</name></author><author><name sortKey="Depicker, A" uniqKey="Depicker A">A Depicker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noel, F" uniqKey="Noel F">F Noel</name></author><author><name sortKey="Malpertuy, A" uniqKey="Malpertuy A">A Malpertuy</name></author><author><name sortKey="De Brevern, Ag" uniqKey="De Brevern A">AG de Brevern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilken, L" uniqKey="Wilken L">L Wilken</name></author><author><name sortKey="Mcpherson, A" uniqKey="Mcpherson A">A McPherson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van, Hg" uniqKey="Van H">HG Van</name></author><author><name sortKey="Allosery, K" uniqKey="Allosery K">K Allosery</name></author><author><name sortKey="De, Bv" uniqKey="De B">BV De</name></author><author><name sortKey="De, St" uniqKey="De S">ST De</name></author><author><name sortKey="Detalle, L" uniqKey="Detalle L">L Detalle</name></author><author><name sortKey="De, Fa" uniqKey="De F">FA De</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Detalle, L" uniqKey="Detalle L">L Detalle</name></author><author><name sortKey="Stohr, T" uniqKey="Stohr T">T Stohr</name></author><author><name sortKey="Palomo, C" uniqKey="Palomo C">C Palomo</name></author><author><name sortKey="Piedra, Pa" uniqKey="Piedra P">PA Piedra</name></author><author><name sortKey="Gilbert, Be" uniqKey="Gilbert B">BE Gilbert</name></author><author><name sortKey="Mas, V" uniqKey="Mas V">V Mas</name></author><author><name sortKey="Millar, A" uniqKey="Millar A">A Millar</name></author><author><name sortKey="Power, Uf" uniqKey="Power U">UF Power</name></author><author><name sortKey="Stortelers, C" uniqKey="Stortelers C">C Stortelers</name></author><author><name sortKey="Allosery, K" uniqKey="Allosery K">K Allosery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steeland, S" uniqKey="Steeland S">S Steeland</name></author><author><name sortKey="Vandenbroucke, Re" uniqKey="Vandenbroucke R">RE Vandenbroucke</name></author><author><name sortKey="Libert, C" uniqKey="Libert C">C Libert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peyvandi, F" uniqKey="Peyvandi F">F Peyvandi</name></author><author><name sortKey="Scully, M" uniqKey="Scully M">M Scully</name></author><author><name sortKey="Kremer Hovinga, Ja" uniqKey="Kremer Hovinga J">JA Kremer Hovinga</name></author><author><name sortKey="Cataland, S" uniqKey="Cataland S">S Cataland</name></author><author><name sortKey="Knobl, P" uniqKey="Knobl P">P Knobl</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Artoni, A" uniqKey="Artoni A">A Artoni</name></author><author><name sortKey="Westwood, Jp" uniqKey="Westwood J">JP Westwood</name></author><author><name sortKey="Mansouri, Tm" uniqKey="Mansouri T">TM Mansouri</name></author><author><name sortKey="Jilma, B" uniqKey="Jilma B">B Jilma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keyaerts, M" uniqKey="Keyaerts M">M Keyaerts</name></author><author><name sortKey="Xavier, C" uniqKey="Xavier C">C Xavier</name></author><author><name sortKey="Heemskerk, J" uniqKey="Heemskerk J">J Heemskerk</name></author><author><name sortKey="Devoogdt, N" uniqKey="Devoogdt N">N Devoogdt</name></author><author><name sortKey="Everaert, H" uniqKey="Everaert H">H Everaert</name></author><author><name sortKey="Ackaert, C" uniqKey="Ackaert C">C Ackaert</name></author><author><name sortKey="Vanhoeij, M" uniqKey="Vanhoeij M">M Vanhoeij</name></author><author><name sortKey="Duhoux, Fp" uniqKey="Duhoux F">FP Duhoux</name></author><author><name sortKey="Gevaert, T" uniqKey="Gevaert T">T Gevaert</name></author><author><name sortKey="Simon, P" uniqKey="Simon P">P Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holz, Jb" uniqKey="Holz J">JB Holz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van, Bs" uniqKey="Van B">BS van</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Skp" uniqKey="Lau S">SKP Lau</name></author><author><name sortKey="Wong, Acp" uniqKey="Wong A">ACP Wong</name></author><author><name sortKey="Lau, Tck" uniqKey="Lau T">TCK Lau</name></author><author><name sortKey="Woo, Pcy" uniqKey="Woo P">PCY Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L Qin</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J Bao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Ja" uniqKey="Demmers J">JA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tai, W" uniqKey="Tai W">W Tai</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Fett, Ca" uniqKey="Fett C">CA Fett</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Tasneem, S" uniqKey="Tasneem S">S Tasneem</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W Tai</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W Tai</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Tseng, Ck" uniqKey="Tseng C">CK Tseng</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author><author><name sortKey="Feng, J" uniqKey="Feng J">J Feng</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W Tai</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Pedotti, M" uniqKey="Pedotti M">M Pedotti</name></author><author><name sortKey="Simonelli, L" uniqKey="Simonelli L">L Simonelli</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C Fett</name></author><author><name sortKey="Fernandez Rodriguez, B" uniqKey="Fernandez Rodriguez B">B Fernandez-Rodriguez</name></author><author><name sortKey="Foglierini, M" uniqKey="Foglierini M">M Foglierini</name></author><author><name sortKey="Agatic, G" uniqKey="Agatic G">G Agatic</name></author><author><name sortKey="Vanzetta, F" uniqKey="Vanzetta F">F Vanzetta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name></author><author><name sortKey="Kamat, V" uniqKey="Kamat V">V Kamat</name></author><author><name sortKey="Badithe, A" uniqKey="Badithe A">A Badithe</name></author><author><name sortKey="Fairhurst, J" uniqKey="Fairhurst J">J Fairhurst</name></author><author><name sortKey="Hunt, C" uniqKey="Hunt C">C Hunt</name></author><author><name sortKey="Strein, J" uniqKey="Strein J">J Strein</name></author><author><name sortKey="Berrebi, A" uniqKey="Berrebi A">A Berrebi</name></author><author><name sortKey="Sisk, Jm" uniqKey="Sisk J">JM Sisk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wan, Y" uniqKey="Wan Y">Y Wan</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Rf" uniqKey="Johnson R">RF Johnson</name></author><author><name sortKey="Bagci, U" uniqKey="Bagci U">U Bagci</name></author><author><name sortKey="Keith, L" uniqKey="Keith L">L Keith</name></author><author><name sortKey="Tang, X" uniqKey="Tang X">X Tang</name></author><author><name sortKey="Mollura, Dj" uniqKey="Mollura D">DJ Mollura</name></author><author><name sortKey="Zeitlin, L" uniqKey="Zeitlin L">L Zeitlin</name></author><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author><author><name sortKey="Huzella, L" uniqKey="Huzella L">L Huzella</name></author><author><name sortKey="Bartos, Cj" uniqKey="Bartos C">CJ Bartos</name></author><author><name sortKey="Bohorova, N" uniqKey="Bohorova N">N Bohorova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van, Dn" uniqKey="Van D">DN van</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="De, We" uniqKey="De W">WE de</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name></author><author><name sortKey="Hanley, Pw" uniqKey="Hanley P">PW Hanley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Zuo, T" uniqKey="Zuo T">T Zuo</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Poon, Km" uniqKey="Poon K">KM Poon</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ju, Tw" uniqKey="Ju T">TW Ju</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Lau, Cc" uniqKey="Lau C">CC Lau</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bannas, P" uniqKey="Bannas P">P Bannas</name></author><author><name sortKey="Hambach, J" uniqKey="Hambach J">J Hambach</name></author><author><name sortKey="Koch Nolte, F" uniqKey="Koch Nolte F">F Koch-Nolte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Gao, T" uniqKey="Gao T">T Gao</name></author><author><name sortKey="Zeng, Y" uniqKey="Zeng Y">Y Zeng</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Xc" uniqKey="Tang X">XC Tang</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Stanhope, J" uniqKey="Stanhope J">J Stanhope</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Peterson, Ec" uniqKey="Peterson E">EC Peterson</name></author><author><name sortKey="Avnir, Y" uniqKey="Avnir Y">Y Avnir</name></author><author><name sortKey="Tallarico, As" uniqKey="Tallarico A">AS Tallarico</name></author><author><name sortKey="Sheehan, J" uniqKey="Sheehan J">J Sheehan</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Sapienza, G" uniqKey="Gonzalez Sapienza G">G Gonzalez-Sapienza</name></author><author><name sortKey="Rossotti, Ma" uniqKey="Rossotti M">MA Rossotti</name></author><author><name sortKey="Tabares Da, Rs" uniqKey="Tabares Da R">RS Tabares-da</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wesolowski, J" uniqKey="Wesolowski J">J Wesolowski</name></author><author><name sortKey="Alzogaray, V" uniqKey="Alzogaray V">V Alzogaray</name></author><author><name sortKey="Reyelt, J" uniqKey="Reyelt J">J Reyelt</name></author><author><name sortKey="Unger, M" uniqKey="Unger M">M Unger</name></author><author><name sortKey="Juarez, K" uniqKey="Juarez K">K Juarez</name></author><author><name sortKey="Urrutia, M" uniqKey="Urrutia M">M Urrutia</name></author><author><name sortKey="Cauerhff, A" uniqKey="Cauerhff A">A Cauerhff</name></author><author><name sortKey="Danquah, W" uniqKey="Danquah W">W Danquah</name></author><author><name sortKey="Rissiek, B" uniqKey="Rissiek B">B Rissiek</name></author><author><name sortKey="Scheuplein, F" uniqKey="Scheuplein F">F Scheuplein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Ph" uniqKey="Chan P">PH Chan</name></author><author><name sortKey="Pardon, E" uniqKey="Pardon E">E Pardon</name></author><author><name sortKey="Menzer, L" uniqKey="Menzer L">L Menzer</name></author><author><name sortKey="De, Ge" uniqKey="De G">GE De</name></author><author><name sortKey="Kumita, Jr" uniqKey="Kumita J">JR Kumita</name></author><author><name sortKey="Christodoulou, J" uniqKey="Christodoulou J">J Christodoulou</name></author><author><name sortKey="Saerens, D" uniqKey="Saerens D">D Saerens</name></author><author><name sortKey="Brans, A" uniqKey="Brans A">A Brans</name></author><author><name sortKey="Bouillenne, F" uniqKey="Bouillenne F">F Bouillenne</name></author><author><name sortKey="Archer, Db" uniqKey="Archer D">DB Archer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Cao, D" uniqKey="Cao D">D Cao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frenken, Lg" uniqKey="Frenken L">LG Frenken</name></author><author><name sortKey="Van Der Linden, Rh" uniqKey="Van Der Linden R">RH van der Linden</name></author><author><name sortKey="Hermans, Pw" uniqKey="Hermans P">PW Hermans</name></author><author><name sortKey="Bos, Jw" uniqKey="Bos J">JW Bos</name></author><author><name sortKey="Ruuls, Rc" uniqKey="Ruuls R">RC Ruuls</name></author><author><name sortKey="De, Gb" uniqKey="De G">GB de</name></author><author><name sortKey="Verrips, Ct" uniqKey="Verrips C">CT Verrips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saerens, D" uniqKey="Saerens D">D Saerens</name></author><author><name sortKey="Kinne, J" uniqKey="Kinne J">J Kinne</name></author><author><name sortKey="Bosmans, E" uniqKey="Bosmans E">E Bosmans</name></author><author><name sortKey="Wernery, U" uniqKey="Wernery U">U Wernery</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S Muyldermans</name></author><author><name sortKey="Conrath, K" uniqKey="Conrath K">K Conrath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P Siddiqui</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tai, W" uniqKey="Tai W">W Tai</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Tseng, Ck" uniqKey="Tseng C">CK Tseng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Poon, Vk" uniqKey="Poon V">VK Poon</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, Tc" uniqKey="Chou T">TC Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W Tai</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Tseng, Ck" uniqKey="Tseng C">CK Tseng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biacchesi, S" uniqKey="Biacchesi S">S Biacchesi</name></author><author><name sortKey="Skiadopoulos, Mh" uniqKey="Skiadopoulos M">MH Skiadopoulos</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name></author><author><name sortKey="Collins, Pl" uniqKey="Collins P">PL Collins</name></author><author><name sortKey="Buchholz, Uj" uniqKey="Buchholz U">UJ Buchholz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Minnesota</li><li>État de New York</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name></noRegion><name sortKey="Chen, Yuehong" sort="Chen, Yuehong" uniqKey="Chen Y" first="Yuehong" last="Chen">Yuehong Chen</name><name sortKey="Du, Enqi" sort="Du, Enqi" uniqKey="Du E" first="Enqi" last="Du">Enqi Du</name><name sortKey="Fan, Ruiwen" sort="Fan, Ruiwen" uniqKey="Fan R" first="Ruiwen" last="Fan">Ruiwen Fan</name><name sortKey="Guo, Yan" sort="Guo, Yan" uniqKey="Guo Y" first="Yan" last="Guo">Yan Guo</name><name sortKey="He, Lei" sort="He, Lei" uniqKey="He L" first="Lei" last="He">Lei He</name><name sortKey="Ji, Kaiyuan" sort="Ji, Kaiyuan" uniqKey="Ji K" first="Kaiyuan" last="Ji">Kaiyuan Ji</name><name sortKey="Li, Jiangfan" sort="Li, Jiangfan" uniqKey="Li J" first="Jiangfan" last="Li">Jiangfan Li</name><name sortKey="Qiu, Hongjie" sort="Qiu, Hongjie" uniqKey="Qiu H" first="Hongjie" last="Qiu">Hongjie Qiu</name><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name></region><name sortKey="Chen, Jiawei" sort="Chen, Jiawei" uniqKey="Chen J" first="Jiawei" last="Chen">Jiawei Chen</name><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><name sortKey="Shang, Jian" sort="Shang, Jian" uniqKey="Shang J" first="Jian" last="Shang">Jian Shang</name><name sortKey="Wang, Yufei" sort="Wang, Yufei" uniqKey="Wang Y" first="Yufei" last="Wang">Yufei Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6146697
|texte= A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29950421" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |